NLRP3-IN-2 是格列本脲合成的中间底物，可抑制心肌细胞中 NLRP3 炎性体的形成，并限制小鼠心肌缺血/再灌注后的梗死面积，而不影响葡萄糖代谢。
货号:ajcx27812
CAS:16673-34-0
分子式:C16H17ClN2O4S
分子量：368.84
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID:24336017 |Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412