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NLRP3-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NLRP3-IN-2图片
规格:98%
分子量:368.84
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
NLRP3-IN-2 是格列本脲合成的中间底物,可抑制心肌细胞中 NLRP3 炎性体的形成,并限制小鼠心肌缺血/再灌注后的梗死面积,而不影响葡萄糖代谢。
货号:ajcx27812
CAS:16673-34-0
分子式:C16H17ClN2O4S
分子量:368.84
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.


Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID:24336017 |Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412