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NS 6740
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS 6740图片
规格:98%
分子量:400.82
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
High affinity α7 nAChR partial agonist; anti-inflammatory
货号:ajcx27404
CAS:753499-14-8
分子式:C19H19F3N2O2.HCl
分子量:400.82
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.


Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID:19845675 |Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J.Neuroimmunol. 251 65 PMID:22884467 |Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID:25497451