IHR 1 是一种细胞膜不可渗透的 Smo 拮抗剂。
货号:ajcx27114
CAS:548779-60-8
分子式:C20H12Cl4N2O2
分子量：454.13
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent Analog also available.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID:25484239