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BRACO 19 trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BRACO 19 trihydrochloride图片
规格:98%
分子量:703.14
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
BRACO 19 trihydrochloride 是一种有效的端粒酶/端粒抑制剂,可防止端粒酶的加帽和催化作用。
货号:ajcx26998
CAS:1177798-88-7
分子式:C35H43N7O2.3HCl
分子量:703.14
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.


Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID:11961134 |Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID:15735037