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Miltefosine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Miltefosine-d4图片
规格:98%
分子量:411.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of miltefosine
货号:ajcx26258
CAS:N/A
分子式:C21H42D4NO4P
分子量:411.6
溶解度:Methanol: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Miltefosine-d4is intended for use as an internal standard for the quantification of miltefosine by GC- or LC-MS. Miltefosine is an inhibitor of CTP:phosphocholine cytidylyltransferase (CCT).1It inhibits liposome-induced CCT activity in MDCK cell homogenates when used at concentrations ranging from 10 to 50 µM, as well as induces translocation of CCT from the cell membrane to the cytosol in MDCK cells. Miltefosine inhibits phosphatidylcholine biosynthesis induced by phorbol 12-myristate 13-acetate in MDCK and HeLa cells when used at a concentration of 50 µM.2It inhibits phosphatidylserine-activated PKC (IC50= 62 µM), as well as PMA-induced morphological changes and proliferation of MDCK cells.3Miltefosine is active against clinical isolate promastigotes ofL. infantum(EC50s = 5-25 µM).4Topical application of miltefosine (0.5%) completely eradicatesL. amazonensisand induces re-epithelialization of lesions in a mouse model of cutaneous leishmaniasis.5Formulations containing miltefosine have been used in the treatment of leishmaniasis and various free-living amoeba infections.


1.Geilen, C.C., Wieder, T., and Reutter, W.Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cellsJ. Biol. Chem.267(10)6719-6724(1992) 2.Wieder, T., Geilen, C.C., and Reutter, W.Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholineBiochem. J.291(Pt. 2)561-567(1993) 3.Geilen, C.C., Haase, R., Buchner, K., et al.The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferationEur. J. Cancer27(12)1650-1653(1991) 4.Espada, C.R., de Castro Levatti, E.V., BoitÉ, M.C., et al.In vitro susceptibility to miltefosine of Leishmania infantum (syn. L. chagasi) isolates from different geographical areas in BrazilMicroorganisms9(6)1228(2021) 5.Peralta, M.F., Usseglio, N.A., Bracamonte, M.E., et al.Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasisDrug Deliv. Transl. Res.12(1)180-196(2022)