包装: | 1mg |
规格: | 98% |
市场价: | 1514元 |
分子量: | 362.8 |
Background:
Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50= 11 nM).1It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50= 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50= 25 µM for theE. colienzyme).2
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)