A key intermediate in aerobic catabolism of phenylacetate in bacteria
货号:ajcx24976
CAS:N/A
分子式:C29H42N7O17P3S·XNa
分子量：885.7
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.¹It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.²

1.MiÑambres, B., MartÍnex-Blanco, H., Olivera, E.R., et al.Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenumJ. Biol. Chem.271(52)33531-33538(1996) 2.Sakamoto, K., Agari, Y., Kuramitsu, S., et al.Phenylacetyl coenzyme A is an effector molecule of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB8J. Bacteriol.193(17)4388-4395(2011)