Mefentrifluconazole 是一种新型的唑类衍生物，广谱抗真菌 (antifungal agent) 剂。Mefentrifluconazole 是具有强效选择性和口服活性真菌 CYP51 的抑制剂 (Kd= 0.5 nM)，但是对人类芳香化酶 (IC50=0.92 μM) 的抑制活性较小。
货号:ajcx16884
CAS:1417782-03-6
分子式:C18H15ClF3N3O2
分子量：397.78
溶解度:DMSO: 100 mg/mL (251.40 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM)[1].

[1]. Tesh SA, et al. Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol®) and the impact upon its toxicity profile. Regul Toxicol Pharmacol. 2019 Aug;106:152-168.