DBCO-PEG4-VC-PAB-DMEA-PNU-159682，一种用于 ADC 的药物-偶联物，由 ADC 接头 DBCO-PEG4-VC-PAB 和有效的 ADC 细胞毒素 DMEA-PNU-159682 组成。 DMEA-PNU-159682 包括来自肝微粒体代谢产物的新霉素 (MMDX) 和 ADC 细胞毒素 PNU-159682。
货号:ajcx35812
CAS:2259318-56-2
分子式:C86H106N10O26
分子量：1695.81
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1].

[1]. John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1