MK-8719 是一种高效、选择性的 O-GlcNAcase (OGA) 抑制剂 (hOGA 的Ki值为 7.9 nM)，具有良好的中枢神经系统渗透性。
货号:ajcx34970
CAS:1382799-40-7
分子式:C9H14F2N2O3S
分子量：268.28
溶解度:DMSO : 100 mg/mL (372.74 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].

MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].

[1]. Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.