Lasiocarpine 是一种有肝毒性吡咯里西定生物碱 ( hepatotoxic PA)，在体内可引起致命的肝静脉闭塞性疾病。Lasiocarpine 只有在代谢转化为毒性中间体后才有毒性，包括 Dehydrolasiocarpine 和 N-oxide。
货号:ajcx34902
CAS:303-34-4
分子式:C21H33NO7
分子量：411.49
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1].

Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1].Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1].Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1].

[1]. Muluneh M Fashe, et al. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine. Chem Res Toxicol. 2015 Oct 19;28(10):2034-44.