SR 7826 是一类双芳基脲衍生的强效、选择性和口服活性 LIM 激酶 (LIMK) 抑制剂，对 LIMK1 的 IC50 为 43 nM。
货号:ajcx27148
CAS:1219728-20-7
分子式:C22H21N5O2
分子量：387.43
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.

Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID:25621531