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SP 100030
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SP 100030图片
规格:98%
分子量:437.65
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
SP 100030 是一种有效的 NF-κB 和 activator protein-1 (AP-1) 双抑制剂(IC50s 分别为 50 和 50 nM)。
货号:ajcx26996
CAS:154563-54-9
分子式:C14H5ClF9N3O
分子量:437.65
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.


Gerlag et al (2000) The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis J.Immunol. 165 1652 PMID:10903776 |Sullivan et al (1998) 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-κB- and AP-1-mediated gene expression identified using solution-phase combinatorial ch J.Med.Chem. 41 413 PMID:9484492 |Moore-Carrasco et al (2007) The AP-1/NF-κB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia. Int.J.Oncol. 30 1239 PMID:17390027