A cellular senescence detection reagent
货号:ajcx26376
CAS:2171036-89-6
分子式:C39H38N8O3S
分子量：698.8
溶解度:DMF: 2 mg/mL,DMSO: 2 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SenTraGor? cell senescence reagent is a detection reagent for lipofuscin, a nondegradable lysosomal marker of cellular senescence.¹It is composed of a Sudan Black B (SBB) derivative conjugated to biotin and can be detected using an anti-biotin antibody. SenTraGor? cell senescence reagent has been used to detect lipofuscin accumulation in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and primary non-small cell lung cancer (NSCLC) samples as well as soluble lipofuscin in serum from patients with various diseases, including dementia and rheumatoid arthritis.^2,3,4

1.Evangelou, K., Lougiakis, N., Rizou, S.V., et al.Robust, universal biomarker assay to detect senescent cells in biological specimensAging Cell16(1)192-197(2017) 2.Evangelou, K., Veroutis, D., Paschalaki, K., et al.Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: Possible implications for viral mutagenesisEur. Respir. J.2102951(2022) 3.Giatromanolaki, A., Kouroupi, M., Balaska, K., et al.A novel lipofuscin-detecting marker of senescence relates with hypoxia, dysregulated autophagy and with poor prognosis in non-small-cell-lung cancerIn Vivo34(6)3187-3193(2020) 4.Rizou, S.V., Evangelou, K., Myrianthopoulos, V., et al.A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in FluidsCellular senescence: Methods and protocols. Methods in molecular biology 1896119-138(2019)