A prodrug form of GS-441524
货号:ajcx25306
CAS:2563617-99-0
分子式:C24H31N5O7
分子量：501.5
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .¹It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC₅₀value of 0.26 µM.

1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)