SV40largeTantigenNLS是一种多肽，来源于SV40大T抗原47-55的氨基酸序列，能够将蛋白运输到细胞核。
货号:ajcx13250
CAS:N/A
分子式:C58H104N20O18S
分子量：1401.7
溶解度:Soluble in H2O
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

SV40 large tumor-antigen (T-ag) nuclear import is enhanced by the protein kinase CK2 (CK2) site (Ser111Ser112) flanking the nuclear localization sequence (NLS)[1]. T-ag NLS can enhance nuclear import, despite the fact that PK-C has been shown to inhibit nuclear import of proteins such as lamin B2[2].

[1]. Xiao CY, et al. Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large T-antigen NLS by importin: effect of conformation. FEBS Lett. 1998 Dec 4;440(3):297-301. [2]. Xiao CY, et al. An engineered site for protein kinase C flanking the SV40 large T-antigen NLS confers phorbol ester-inducible nuclear import. FEBS Lett. 1998 Oct 9;436(3):313-7.