Tuberculosis inhibitor 3 (compound 2i) 对敏感性，和耐性的MTB 菌株均具有良好的抗结核活性。Tuberculosis inhibitor 3 (compound 2i) 显示出良好的药代活性和口服生物利用度。
货号:ajcx33678
CAS:2219325-28-5
分子式:C21H22F6N4O3S
分子量：524.48
溶解度:DMSO : 27.5 mg/mL (52.43 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC< 0.016 µg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].

Tuberculosis inhibitor 3 (compound 2i, 50 mg/kg) shows acceptable PK properties with the AUC of 2489 h•ng/mL) is. The Tmax of Tuberculosis inhibitor 3 is 0.25 h[1].

[1]. Kai Lv, et al. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur J Med Chem. 2018 May 10;151:1-8.