3,4,5-Trihydroxycinnamicaciddecylester是一种高效的脂质吸收和积累抑制剂，具有抗肥胖作用。3,4,5-Trihydroxycinnamicaciddecylester是一种胰腺脂肪酶(pancreaticlipase)抑制剂，其EC50大约为0.9μM。
货号:ajcx31726
CAS:1770778-45-4
分子式:C19H28O5
分子量：336.42
溶解度:DMSO: 100 mg/mL (297.25 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].

3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro[1].3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC50 value being approximately 0.9 μM[1].3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation[1].

3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally[1]. Animal Model: 6 weeks old Male ddY mice[1]

[1]. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.