EMI48是EMI1的衍生物，EMI48比EMI1对突变型EGFR具有更大的效力。EMI48抑制EGFR三重突变体。
货号:ajcx30582
CAS:34564-13-1
分子式:C21H20N2O3
分子量：348.4
溶解度:DMSO: 9.26 mg/mL (26.58 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].

EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

[1]. Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586.