8-Azaadenosine 是一种有效的 ADAR1 抑制剂和 A-to-I 编辑抑制剂。
货号:ajcx27850
CAS:10299-44-2
分子式:C9H12N6O4
分子量：268.23
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID:27292188 |Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID:27494666