Potent and selective IRE1α inhibitor
货号:ajcx27426
CAS:2250019-92-0
分子式:C31H29ClN6O3S.HCl
分子量：637.58
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933