An active metabolite of estrone
货号:ajcx26068
CAS:58562-33-7
分子式:C19H24O3
分子量：300.4
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-methoxy Estrone is an active metabolite of the endogenous estrogen estrone .¹It is formed from estrone by catechol-O-methyltransferase (COMT). 4-methoxy Estrone (10 and 100 nM) increases the proliferation of human umbilical vein endothelial cells (HUVECs).²

1.Dawling, S., Roodi, N., Mernaugh, R.L., et al.Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoformsCancer Res.61(18)6716-6722(2001) 2.Lippert, C., Seeger, H., Mueck, A.O., et al.The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cellsLife Sci.67(13)1653-1658(2000)