SN-011 是一种有效的选择性小鼠和人类 STING 抑制剂，对 STING 信号传导的 IC50 为 76 nM。
货号:ajcx25756
CAS:2249435-90-1
分子式:C25H19FN2O4S
分子量：462.5
溶解度:DMF: 5 mg/ml,DMSO: 25 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SN-011 is a stimulator of interferon genes (STING) antagonist.¹It binds to the STING cyclic dinucleotide binding site (K_d= 4.03 nM) and inhibits 2’3’-cGAMP-inducedIfnbexpression in mouse embryonic fibroblasts (MEFs), mouse bone marrow-derived macrophages (BMDMs), and human foreskin fibroblasts (HFFs; IC₅₀s = 127.5, 107.1, and 502.8 nM, respectively). SN-011 (1 µM) impairs recruitment of IFN regulatory factor 3 (IRF3) or TANK-binding kinase 1 (TBK1) to the STING signalosome in HEK293T cells overexpressing tagged wild-type or SAVI-linked mutant STING and IRF3 or TBK1, as well as inhibits translocation of STING from the endoplasmic reticulum (ER) to the Golgi induced by herpes simplex virus 1 (HSV-1) in HFFs.In vivo, SN-011 (5 mg/kg) increases survival and reducesIfnbmRNA levels in theTrex1^-/-mouse model of Aicardi-GoutiÈres syndrome, an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction.

1.Hong, Z., Mei, J., Li, C., et al.STING inhibitors target the cyclic dinucleotide binding pocketProc. Natl. Acad. Sci. USA.118(24)e2105465118(2021)