An active metabolite of brinzolamide
货号:ajcx25390
CAS:N/A
分子式:C11H19N3O5S3·HCl
分子量：405.9
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .^1,2It inhibits CAII and CAIV (IC₅₀s = 0.136 and 165 nM, respectively).¹

1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tandem mass spectrometry method for determining carbonic anhydrase inhibitors and their metabolites in urine and hairDrug Test Anal.13(8)1552-1560(2021)