Tribenoside 是一种血管保护剂，可用于痔疮的研究。
货号:ajcx25122
CAS:10310-32-4
分子式:C29H34O6
分子量：478.6
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tribenoside is a vasoprotective agent with anti-allergic and anti-inflammatory activities.^1,2It inhibits agonist-induced contractions in various isolated porcine venous preparations when used at concentrations ranging from 10 to 30 µg/ml.¹Tribenoside inhibits compound 48/80-induced histamine release in isolated rat peritoneal cells (EC₅₀= 10 µg/ml).³It reduces decreases in proteoglycan levels and the severity of cartilage destruction in the inflamed joints in a rabbit model of surgically induced osteoarthritis when administered at doses of 100 and 200 mg/kg per day.⁴Formulations containing tribenoside have been used in the treatment of hemorrhoids and varicose veins.

1.Jaques, R.The activity pattern, in isolated veins, of a benzyl glucofuranoside derivative possessing combined anti-inflammatory and venotropic effectsPharmacology4(4)193-202(1970) 2.Jaques, R.The pharmacological activity of tribenosidePharmacology15(5)445-460(1977) 3.RÜegg, M., and Jaques, R.Tribenoside as an inhibitor of chemically induced histamine releaseExperientia30(4)399-401(1974) 4.Colombo, C., Butler, M., Hickman, L., et al.A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemicallyArthritis Rheum.26(9)1132-1139(1983)