A lupane triterpenoid with anti-inflammatory and anticancer activities
货号:ajcx24132
CAS:27686-35-7
分子式:C32H52O3
分子量：484.8
溶解度:DMF: 1 mg/ml,DMSO: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.^1,2It inhibits LPS-induced nitric oxide (NO) and prostaglandin E₂production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC₅₀s = 4.7 and 1.7 µM, respectively).¹28-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC₅₀s = 14.37, 10.96, and 11.38 µM, respectively).²

1.Reyes, C.P., NÚÑez, M.J., JimÉnez, I.A., et al.Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2Bioorg. Med. Chem.14(5)1573-1579(2006) 2.Kommera, H., Kaluderovi?, G.N., Kalbitz, J., et al.Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cellsInvest. New Drugs29(2)266-272(2011)