An internal standard for the quantification of zanamivir
货号:ajcx23754
CAS:1276528-62-1
分子式:C11[13C]H20N2[15N]2O7
分子量：335.3
溶解度:Water: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Zanamivir-¹³C,¹⁵N₂is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.¹It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC₅₀values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC₅₀values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.

1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)