m-PEG8-Amine 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联药物 (ADCs) 的合成。
货号:ajcx33930
CAS:869718-81-0
分子式:C17H37NO8
分子量：383.48
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Joshua D. Thoma, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.