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TH1338
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH1338图片
规格:98%
分子量:391.42
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
TH1338 (compound 3b) 是具有口服活性的喜树碱的衍生物,是有潜力的抗癌化合物,在体外表现出优异的肿瘤细胞毒性的效果。TH1338 (compound 3b) 具有显著的血脑屏障透过性,良好的外排泵特性和低血液学毒性。
货号:ajcx33792
CAS:1258494-60-8
分子式:C22H21N3O4
分子量:391.42
溶解度:DMSO : 10 mg/mL (25.55 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2].

TH1338 (compound 3b) demonstrates significant brain penetration when dosed orally in mice[1].TH1338 (compound 3b) exhibits potent anti-tumor activity in H460 (NSCLC) human tumor xenograft model[1].

[1]. Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23.
[2]. Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942.