您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > [Leu31,Pro34]-Neuropeptide Y(human,rat)TFA
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
[Leu31,Pro34]-Neuropeptide Y(human,rat)TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:4354.76
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种特定的神经肽 Y Y1 受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 也激活 Y4,Y5。[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 可以增加麻醉大鼠的血压,也增加饮食摄入量。
货号:ajcx33040
CAS:N/A
分子式:C191H285F3N54O58S
分子量:4354.76
溶解度:H2O : 50 mg/mL (11.48 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake[1][2].

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has Ki values of 0.39 nM, 0.499 nM, 0.31 nM for Y1, Y4, Y5 in HEK cell lines. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA has a Ki of >1000 for Y2 in HEK cell lines[2].

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)[3].

[1]. K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58.
[2]. J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.
[3]. A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15.