Lenalidomide-C5-NH2hydrochloride是一种基于Lenalidomide的，可募集CRBN蛋白的Cereblon配体。Lenalidomide-C5-NH2可通过linker与靶蛋白配体连接，形成PROTAC分子，比如MDM2的PROTAC降解剂。
货号:ajcx30908
CAS:N/A
分子式:C18H24ClN3O3
分子量：365.85
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.