(-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。
货号:ajcx29792
CAS:84709-25-1
分子式:C20H20O5
分子量：340.37
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].

(-)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].(-)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation[1].

[1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (-)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873-1883.