Estrogen receptor antagonist 2 是一种有效的口服活性雌激素受体 (ER) 拮抗剂，例17，源于专利 US20180111931A1。Estrogen receptor antagonist 2 可以用于乳腺癌的相关研究。
货号:ajcx29148
CAS:2222844-89-3
分子式:C24H28F4N6
分子量：476.51
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer[1].

Estrogen receptor antagonist 2 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft[1].Estrogen receptor antagonist 2 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice[1]. Animal Model: Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice[1]

[1]. Bernard Christophe Barlaam, etal. Chemical compounds. Patent US20180111931.