| 规格: | 98% |
| 分子量: | 321.33 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
Background:
GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID:23472935 |Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID:30016665
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