Potent and selective CXCR2 antagonist
货号:ajcx27166
CAS:1029521-30-9
分子式:C15H11F2N3OS
分子量：319.33
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Porter et al (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 24 3285 PMID:24974342