JAK2 inhibitor
货号:ajcx26856
CAS:130065-61-1
分子式:C22H44N2.2HCl
分子量：409.52
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID:21512135 |QuintÁs-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID:20372971