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L-Kynurenine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Kynurenine-d4图片
规格:98%
分子量:212.2
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
L-犬尿氨酸-d4 是氘标记的 L-犬尿氨酸。
货号:ajcx25960
CAS:2672568-86-2
分子式:C10H8D4N2O3
分子量:212.2
溶解度:DMF: 0.5mg/mL,DMSO: 1mg/mL,Ethanol: 2mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:


L-Kynurenine-d4is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan .1It is formed from tryptophanviatryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR; Kd =~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50= 12.3 µM).2It decreases intracellular concentrations of NAD+in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner.3L-Kynurenine in combination with IFN-γ reduces lung injury induced byA. fumigatusinfection in thep47phox-/-mouse model of chronic granulomatous disease.4


1.Stone, T.W., Forrest, C.M., and Darlington, L.G.Kynurenine pathway inhibition as a therapeutic strategy for neuroprotectionFEBS J.279(8)1386-1397(2012) 2.Opitz, C.A., Litzenburger, U.M., Sahm, F., et al.An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptorNature478(7368)197-203(2011) 3.Braidy, N., Grant, R., Brew, B.J., et al.Effects of kynurenine pathway metabolites on intracellular NAD+ synthesis and cell death in human primary astrocytes and neuronsInt. J. Tryptophan Res.261-69(2009) 4.Romani, L., Fallarino, F., De Luca, A., et al.Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous diseaseNature451(7175)211-215(2008)