规格: | 98% |
分子量: | 151.2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
L-Glutamine-d5is intended for use as an internal standard for the quantification of L-glutamine by GC- or LC-MS. L-Glutamine is a non-essential amino acid involved in many biochemical processes. It is synthesizedin vivoby glutamate and ammonia.1It serves as a substrate for glutamine synthetase in neurons for the biosynthesis of the major excitatory and inhibitory neurotransmitters glutamate and GABA.2L-Glutamine decreases adhesion of sickle red blood cells (RBCs) to human umbilical vein endothelial cells (HUVECs) when incubatedex vivowith patient-derived autologous plasma either alone or with LPS.3It has commonly been used in cell culture media. Formulations containing L-glutamine have been used in the treatment of sickle cell disease.
1.Eisenberg, D., Gill, H.S., Pfluegl, G.M.U., et al.Structure-function relationships of glutamine synthetasesBiochim Biophys. Acta.1477(1-2)122-145(2000) 2.Bak, L.K., Schousboe, A., and Waagepetersen, H.S.The glutamate/GABA-glutamine cycle: Aspects of transport, neurotransmitter homeostasis and ammonia transferJ. Neurochem.98(3)641-653(2006) 3.Niihara, Y., Matsui, N.M., Shen, Y.M., et al.L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cellsBMC Blood Disord.5(4)(2005)