A purine nucleotide and an intermediate in the purine nucleotide cycle
货号:ajcx25428
CAS:N/A
分子式:C14H14N5O11P·4NH4
分子量：531.4
溶解度:PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.¹It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.²Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.³It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 µM.⁴

1.Waarde, A.Operation of the purine nucleotide cycle in animal tissuesBiol. Rev. Camb. Philos. Soc.63(2)259-298(1988) 2.Halonen, J., and Nedergaard, J.Adenosine 5’-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channelJ. Membr. Biol.188(1)183-197(2002) 3.Gooding, J.R., Jensen, M.W., Dai, X., et al.Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolismCell Rep.13(1)157-167(2015) 4.Nishida, Y., and Miyamoto, T.Contractile effect of succinylpurines on guinea pig uterusGen. Pharmacol.19(2)277-279(1988)