LY456236 HCl is a selective mGlu1 receptor antagonist (IC50 are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively). LY456236 HCl reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively. References: Kanaya S, Komatsu H, Shimauchi H, Nemoto E. Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways. Connect Tissue Res. 2016 Sep;57(5):417-26. doi: 10.1080/03008207.2016.1195826. PubMed PMID: 27261070.

纯度：≥98%

CAS：338736-46-2