UC-514321 是NSC370284 的结构类似物，且活性更高，靶向STAT3/5 并选择性抑制TET1 的表达。UC-514321 体内体外均表现出良好的抗急性髓系白血病的活性，并具有较低的毒性。
货号:ajcx16666
CAS:299420-83-0
分子式:C26H35NO5
分子量：441.56
溶解度:DMSO: 62.5 mg/mL (141.54 mM); Ethanol: 50 mg/mL (113.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1].

[1]. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.