GS-443902 是一种有效的病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 抑制剂，对 TP RdRp，RSV RdRp 和 HCV RdRp 的 IC50 分别为 5.6 &#181M，1.1 &#181M 和 5 &#181M。GS-443902 是 Remdesivir 的活性三磷酸盐代谢产物。
货号:ajcx16256
CAS:1355149-45-9
分子式:C12H16N5O13P3
分子量：531.2
溶解度:H2O: 100 mg/mL (188.25 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GS-443902 (Remdesivir metabolite) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 5.6 &#181M, 1.1 &#181M, 5 &#181M for TP RdRp, RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].

[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [2]. Cho A, et al. Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. [3]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.