LY320135 is a selective antagonist for the brain CB1 receptor. LY320135 has a greater than 70-fold higher affinity for the CB1 than the peripheral CB2 receptor. The Kis for LY320135 at the CB1 and CB2 receptors were 224 nM and > 10 microM, respectively. References: Felder CC, Joyce KE, Briley EM, Glass M, Mackie KP, Fahey KJ, Cullinan GJ, Hunden DC, Johnson DW, Chaney MO, Koppel GA, Brownstein M. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7. PubMed PMID: 9435190.

纯度：≥98%

CAS：176977-56-3