HS-27，一种荧光Hsp90抑制剂，检测完整组织标本表面Hsp90的表达。HS-27由SNX-5422的核心元素组成，SNX-5422是一种Hsp90抑制剂，通过PEG连接物与荧光素衍生物(异硫氰酸荧光素或FITC)连接，后者与外周表达的Hsp90结合。HS-27在乳腺癌的观察与研究中有潜在的应用。
货号:ajcx32448
CAS:1562024-11-6
分子式:C52H60N6O12S
分子量：993.13
溶解度:DMSO: 125 mg/mL (125.86 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1].

HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. HS-27 fluorescence is greater in tumor than non-tumor tissue[1].

[1]. Crouch BT, et al. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Sci Rep. 2019 Mar 5;9(1):3461.