A nucleoside precursor
货号:ajcx26046
CAS:5399-87-1
分子式:C10H11ClN4O4
分子量：286.7
溶解度:DMF: 2 mg/ml,DMSO: 5 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

6-Chloropurine riboside is a nucleoside precursor.¹It has been used in the synthesis of adenosine derivatives with antiproliferative activity in human gastric cancer cells expressing the adenosine A₃receptor. 6-Chloropurine riboside has also been used in the synthesis of N⁶-benzyladenosine derivatives with antiproliferative activity in a variety of cancer cells or inhibitory activity againstT. gondiireplication in CRL-1634/Hs27 human skin fibroblasts.^2,3

1.Zurita, F.V., Vega, N.B., and Cabrera, M.G.Semisynthesis, characterization and evaluation of new adenosine derivatives as antiproliferative agentsMolecules23(5)1111(2018) 2.Dolezal, K., Popa, I., HauserovÁ, E., et al.Preparation, biological activity and endogenous occurrence of N6-benzyladenosinesBioorg. Med. Chem.15(11)3737-3747(2007) 3.Kim, Y.A., Sharon, A., Chu, C.K., et al.Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agentsBiochem. Pharmacol.73(10)1558-1572(2007)