A neuropeptide with diverse biological activities
货号:ajcx23224
CAS:N/A
分子式:C18H32D5NO2
分子量：304.5
溶解度:DMF: 2 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.¹PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activityin vitro.²PEA is an endocannabinoid which has been shown to significantly elevate cAMP in cells expressing CB₂receptors. However, its affinity for CB₂receptors is relatively low, at about 10 µM. CB₁receptors have no appreciable affinity for PEA.³

1.Bachur, N.R., Masek, K., Melmon, K.L., et al.Fatty acid amides of ethanolamine in mammalian tissuesJ. Biol. Chem.2401019-1024(1965) 2.Ganley, O.H., Graessle, O.E., Robinson, H.J., et al.Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithinJournal of Laboratory and Clinical Medicine51709-714(1958) 3.Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090)1946-1949(1992)