Mobocertinib (TAK-788) 是一种具有口服活性且不可逆的 EGFR/HER2 抑制剂。 Mobocertinib 有效抑制含有激活 EGFRex20ins 突变的致癌变体，对野生型 EGFR 具有选择性。 Mobocertinib 可用于 NSCLC 研究。
货号:ajcx22982
CAS:1847461-43-1
分子式:C32H39N7O4
分子量：585.7
溶解度:DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.^1,2It is selective for the HER2 exon 20 mutants HER2^V659E, HER2^G660D, HER2^G309E, and HER2^S310Fover wild-type EGFR in Ba/F3 cells.¹

1.Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811P2(13-32)(2018) 2.Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599P1(13-44)(2018)