PT-S58 is a PPAR β/δ full antagonist, and a analogue of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPARβ/δ. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT. References: Naruhn S, Toth PM, Adhikary T, Kaddatz K, Pape V, Dorr S, Klebe G, Müller-Brüsselbach S, Diederich WE, Müller R. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38. doi: 10.1124/mol.111.074039. Epub 2011 Aug 23. PubMed PMID: 21862691.

纯度：≥98%

CAS：1356497-92-1