Sulfo-ara-F-NMN(CZ-48)是一种烟酰胺单核苷酸(NMN)的类似物。Sulfo-ara-F-NMN选择性激活SARM1，但抑制CD38(IC50约为10μM)。Sulfo-ara-F-NMN诱导细胞内环状ADP-核糖(cADPR)的产生。
货号:ajcx32484
CAS:1374663-29-2
分子式:C11H14FN2O6PS
分子量：352.28
溶解度:DMSO: 210 mg/mL (596.12 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].

Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].

[1]. Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.