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Tos-O-C4-NH-Boc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tos-O-C4-NH-Boc图片
包装:500mg
规格:98%
市场价:445元
分子量:343.44

产品介绍
Tos-O-C4-NH-Boc是一种PROTAClinker,属于alkylether类。Boc-NH-C6-amido-C4-acid可用于合成PROTAC分子,例如BSJ-03-204。
货号:ajcx32208
CAS:180851-50-7
分子式:C16H25NO5S
分子量:343.44
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 [1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.